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. 2022 Aug 11;9(9):1437–1448. doi: 10.1002/acn3.51645

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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cNfL concentrations before treatment initiation. (A) Association between age and cNfL concentration before treatment initiation; each icon represents an individual person; shades of purple distinguish SMA type. Solid line indicates upper limit of normal (reported by Yilmaz et al.), dashed line shows predicted cNfL concentration (calculated using regression formula determined by Yilmaz et al.). (B) Correlation between cGFAP and cNfL concentration before treatment initiation; each icon represents an individual person; shades of gray distinguish SMA type. cNfL, neurofilament light chain concentration in cerebrospinal fluid; cGFAP, glial fibrillary acidic protein concentration in cerebrospinal fluid; N = 73. [Colour figure can be viewed at wileyonlinelibrary.com]