Table 1.
Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value in Multiplex Electrochemiluminescence Assay, Correlated to Each Corresponding Islet Autoantibody Positivity by Radio-Binding Assay
| Cutoff | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|
| GADA | 0.010 | 81% | 99% | 92% | 82% |
| IA-2A | 0.007 | 89% | 99% | 89% | 72% |
| ZnT8A | 0.007 | 83% | 99% | 83% | 74% |
| IAA | 0.006 | 69% | 99% | 80% | 74% |
| TGA | 0.008 | 96% | 100% | 89% | 100% |
GADA, glutamic acid decarboxylase; IA-2A, islet antigen 2; IAA, including antibodies to insulin; NPV, negative predictive value; PPV, positive predictive value; TGA, transglutaminase; ZnT8A, zinc transporter 8.