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. 2022 Apr 11;29(41):62626–62636. doi: 10.1007/s11356-022-20144-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — NAI intervention alleviates depression-like behavior in mice after stress exposure. a Diagram of experiment design and timeline. b Sucrose preference in the Sucrose preference (SPT). The one-way ANOVA test measured the significant differences between these groups {F[3,92] = 11.247, ***P < 0.0001; Tamhane’s T2 multiple comparisons test showed **P = 0.003 (Con vs. CMS); *P = 0.012 (CMS vs. CMS + NAI); **P = 0.009 (CMS vs. Con + NAI)}. c Time spent immobile in the tail suspension test (TST). The one-way ANOVA test measured the significant differences between these groups {F[3,90] = 10.431, ***P < 0.0001; Tamhane’s T2 multiple comparisons test showed ***P < 0.0001 (Con vs. CMS); **P = 0.003 (CMS vs. Con + NAI); ***P < 0.0001 (CMS vs. CMS + NAI)}. d Time spent immobile in the forced swimming test (FST). The one-way ANOVA test with Tamhane’s T2 multiple comparisons test measured the significant differences between these groups {F[3,98] = 2.475, P = 0.066}. e Spontaneous alternation in Y maze test (YMT). The one-way ANOVA test with Bonferroni multiple comparisons test measured the significant differences between these groups {F[3,122] = 0.366, P = 0.778}. f Body weight evaluated before the experiment. The one-way ANOVA test with Bonferroni multiple comparisons test measured the significant differences between these groups {F[3,87] = 2.509, P = 0.064}. g Body weight evaluated after 30-day CMS treatment in mice with or without NAI exposure. The one-way ANOVA test measured the significant differences between these groups {F[3,87] = 45.286, ***P < 0.0001; Bonferroni multiple comparisons test showed ***P < 0.0001 (Con vs. CMS); ***P < 0.0001 (Con vs. CMS + NAI); ***P < 0.0001 (CMS vs. Con + NAI); ***P < 0.0001 (CMS + NAI vs. Con + NAI)}. h Time spent on the rod in the rotarod test (RTT). The one-way ANOVA test with Tamhane’s T2 multiple comparisons test measured the significant differences between these groups {F[3,81] = 2.681, P = 0.052}. i Distance traveled in the open field test (OFT). The one-way ANOVA test with Bonferroni multiple comparisons test measured the significant differences between these groups {F[3,77] = 2.338, P = 0.08}. *P < 0.05, **P < 0.01, ***P < 0.001. Data are presented as mean ± S.E.M