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Anti-nuclear antibodies (ANA) detected on HEp2 cells by indirect immunofluorescence. The large nuclei of this laryngeal tumour cell line allow clear visualization of the ANA patterns. A Homogeneous. B Speckled. C Nucleolar. D Multiple nuclear dots. E Rim-like. A and B, and to a much lower frequency C, are found in autoimmune hepatitis type 1, A being by far the most common. D and E are patterns frequently encountered in primary biliary cholangitis
