. 2022 May 20;61(7):3471–3486. doi: 10.1007/s00394-022-02860-9

Table 4.

Multivariable linear regression models for the relationship between the children’s Dietary Inflammatory Score (cDIS) at 7, 10 and 13 years and cardiometabolic risk score at 24 years, using imputed datasets in the ALSPAC cohort (n = 1957)

children's Dietary Inflammatory Score (cDIS)^a	Cardiometabolic Risk (CMR) score at 24 years
	N	Crude		Minimally adjusted^b		Fully adjusted^c
	N	β (95% CI )	p value	β (95% CI )	p value	β (95% CI )	p value
cDIS at 7 years
Tertile 1	660	Reference		Reference		Reference
Tertile 2	657	0.25 (0.08, 0.41)	0.004	0.28 (0.12, 0.45)	0.001	0.26 (0.09, 0.42)	0.002
Tertile 3	640	0.27 (0.10, 0.43)	0.002	0.33 (0.17, 0.50)	< 0.001	0.28 (0.11, 0.44)	0.001
Continuous^d	1957	0.08 (0.03, 0.12)	0.001	0.10 (0.06, 0.15)	< 0.001	0.08 (0.04, 0.13)	< 0.001
cDIS at 10 years
Tertile 1	657	Reference		Reference		Reference
Tertile 2	648	0.08 (− 0.09, 0.24)	0.376	0.11 (− 0.05, 0.28)	0.182	0.08 (− 0.08, 0.25)	0.323
Tertile 3	652	0.12 (− 0.05, 0.28)	0.177	0.18 (0.01, 0.35)	0.034	0.12 (− 0.05, 0.29)	0.152
Continuous^d	1957	0.04 (− 0.004, 0.09)	0.073	0.06 (0.02, 0.11)	0.007	0.04 (− 0.001, 0.09)	0.054
cDIS at 13 years
Tertile 1	656	Reference		Reference		Reference
Tertile 2	656	0.08 (− 0.08, 0.25)	0.332	0.13 (− 0.04, 0.29)	0.144	0.08 (− 0.08, 0.25)	0.322
Tertile 3	645	0.09 (− 0.07, 0.26)	0.276	0.18 (0.01, 0.35)	0.042	0.11 (− 0.06, 0.28)	0.209
Continuous^d	1957	0.03 (− 0.01, 0.07)	0.167	0.06 (0.01, 0.11)	0.010	0.04 (− 0.005, 0.08)	0.079
cDIS tracking 7–10–13 years^e
cDIS low	593	Reference		Reference		Reference
cDIS mixed	285	0.35 (0.13, 0.57)	0.002	0.36 (0.14, 0.57)	0.001	0.28 (0.06, 0.50)	0.012
cDIS medium	521	0.22 (0.04, 0.40)	0.017	0.27 (0.09, 0.45)	0.003	0.24 (0.06, 0.41)	0.010
cDIS high	558	0.20 (0.03, 0.38)	0.025	0.30 (0.12, 0.48)	0.001	0.22 (0.04, 0.41)	0.015

^acDIS: energy adjusted children's Dietary Inflammatory score. ^bMinimally Adjusted: Multivariable regression model adjusted for sex and dietary misreporting. ^cFully Adjusted: Multivariable regression model adjusted for sex, dietary misreporting, maternal highest education level, family highest social class and physical activity level at 11 years (for analysis of cDIS at 7 and 10 years) and physical activity at 13 years (for analysis of cDIS at 13 years). ^dEstimated mean change in CMR z-score associated with a 1 unit increase in cDIS. ^ecDIS tracking; low indicates first tertile of cIDS at least twice from 7–10–13 years, mixed indicates different tertiles of cDIS at 7–10–13 years, medium indicates second tertile of cDIS at least twice from 7–10–13 years, high indicates high tertile of cDIS at least twice from 7–10–13 years