Table 6.
Association between the children’s Dietary Inflammatory Score (cDIS) at 7, 10 and 13 years and individual cardiometabolic risk factors at 24 years, using imputed datasets in the ALSPAC cohort (n = 1957)
| CMR Factors z-score at 24 years (n = 1957) | Children’s Dietary Inflammatory Score (cDIS), per 1-unit increment | |||||
|---|---|---|---|---|---|---|
| cDIS at 7 years | cDIS at 10 years | cDIS at 13 years | ||||
| β (95% CI )a | p value | β (95% CI )a | p value | β (95% CI )a | p value | |
| Anthropometric | ||||||
| Body Mass Index | 0.16 (0.09, 0.23) | < 0.001 | 0.08 (0.01, 0.14) | 0.032 | 0.07 (− 0.00, 0.14) | 0.057 |
| Fat Mass Indexb | 0.06 (0.03, 0.09) | < 0.001 | 0.03 (0.00, 0.06) | 0.022 | 0.03 (0.0002, 0.06) | 0.050 |
| Waist circumference | 0.05 (0.02, 0.08) | 0.002 | 0.04 (0.01, 0.07) | 0.012 | 0.02 (− 0.01, 0.06) | 0.171 |
| Blood lipids | ||||||
| Total cholesterol | 0.00 (− 0.03, 0.03) | 0.786 | 0.00 (− 0.02, 0.04) | 0.595 | 0.00 (− 0.03, 0.03) | 0.891 |
| HDL-cholesterolb | 0.03 (− 0.0004, 0.06) | 0.053 | 0.01 (− 0.01, 0.04) | 0.335 | 0.02 (− 0.01, 0.05) | 0.267 |
| LDL-cholesterolb | 0.02 (− 0.01, 0.05) | 0.196 | 0.01 (− 0.02, 0.03) | 0.595 | 0.01 (− 0.12, 0.04) | 0.495 |
| Triacylglycerolb | 0.09 (− 0.02, 0.20) | 0.121 | 0.01 (− 0.02, 0.04) | 0.492 | − 0.01 (− 0.04, 0.02) | 0.742 |
| Blood pressure | ||||||
| Systolic BP | 0.05 (0.02, 0.08) | 0.003 | 0.03 (− 0.004, 0.06) | 0.085 | 0.03 (− 0.003, 0.06) | 0.074 |
| Diastolic BP | 0.04 (0.01, 0.07) | 0.004 | 0.01 (− 0.02, 0.04) | 0.508 | 0.01 (− 0.02, 0.04) | 0.347 |
| Mean Arterial BPb | 0.05 (0.02, 0.08) | 0.002 | 0.02 (− 0.01, 0.05) | 0.245 | 0.02 (− 0.01, 0.05) | 0.164 |
| Glucose metabolism | ||||||
| Insulin | 0.05 (0.02, 0.08) | 0.001 | 0.03 (− 0.01, 0.06) | 0.066 | 0.03 (− 0.0005, 0.06) | 0.054 |
| Glucose | 0.00 (− 0.03, 0.03) | 0.926 | − 0.01 (− 0.04, 0.02) | 0.515 | 0.00 (− 0.03, 0.03) | 0.991 |
| HOMA-IRb | 0.05 (0.02,0.08) | 0.001 | 0.02 (− 0.005, 0.05) | 0.103 | 0.03 (− 0.002, 0.06) | 0.069 |
cDIS energy adjusted children's Dietary Inflammatory Score, CMR score Cardiometabolic risk score, HOMA-IR Homeostatic Model Assessment of Insulin Resistance, BP Blood Pressure, HDL cholesterol High-density lipoprotein cholesterol, LDL cholesterol low-density lipoprotein cholesterol
aBeta coefficients (95% confidence intervals) derived from multivariable linear regression models adjusted for sex, dietary misreporting, physical activity at 11 and 13 years, mother's highest education level, highest family social class
bCardiometabolic parameters included in the Cardiometabolic Risk Score