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. 2022 Sep 10;13(9):782. doi: 10.1038/s41419-022-05226-5

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© The Author(s) 2022, corrected publication 2022

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Fig. 2 — A Venn diagram of target miRNAs established by overlapping circBank and starbase databases. B Relative miR-124-3p and miR-605-3p expression of CD patients and NCs was quantified by qRT-PCR test. C The predicted secondary structures of miR-124. The predicted binding sites between circGMCL1 and miR-124-3p in human species based on starbase and circBank databases (D), and OECloud based on miRanda (E). F The predicted binding sites between circGMCL1 and miR-124-3p in murine species based on the starbase. The linear correlation between relative miR-124-3p expression and CRP (G), CDAI (H), SES-CD (I), and circGMCL1 expression (J) in CD patients (n = 75) as determined by qRT-PCR test. K FISH analyses of circGMCL1 and miR-124-3p in colon tissues from CD and NCs. The relative expression of circGMCL1 (L) and miR-124-3p (M) in isolated epithelial cells from CD and NCs. MiRNA, microRNA, CD Crohn’s disease, NC normal control, qRT-PCR quantitative real time-polymerase chain reaction, CRP C-reactive protein, CDAI Crohn’s disease activity index, SES-CD simple endoscopic score for Crohn’s disease, MFE minimum free energy, FISH fluorescence in situ hybridization, ns, not significant. Data are expressed as mean ± SD. ***P < 0.001 by Student’s t tests.