Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 10;13(9):782. doi: 10.1038/s41419-022-05226-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Scatter plots (A), volcano plots (B), and heatmap (C) showing mRNA expression profile of colon tissues from CD patients and NCs (threshold: FC > 3, P < 0.05). The histogram (D) and bubble (E) displaying results of Go enrichment analyses, including BP, MF, and CC for the dysregulated mRNAs. Relative circGMCL1 expression in colon tissues from CD patients and NCs as determined by qRT-PCR analysis. F Venn diagram displaying the overlapping miR-124-3p target predicting algorithms and up-regulated mRNAs. G The predicted binding sites between miR-124-3p and ANXA7 in human and mouse species based on starbase database. Relative ANXA7 expression in colon tissues H and isolated epithelial cells I of CD patients and NCs as determined using qRT-PCR assay. The linear correlation between relative ANXA7 expression and miR-124-3p J, circGMCL1 K in CD patients (n = 75) as evaluated by qRT-PCR analysis. ANXA7 annexin 7, CD Crohn’s disease, NC normal control, FC fold change, GO gene ontology, BP biological processes, MF molecular function, CC cellular component, qRT-PCR quantitative real time-polymerase chain reaction. Data are presented as mean ± SD. ***P < 0.001 by Student’s t tests.