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. 2022 Sep 10;13(9):782. doi: 10.1038/s41419-022-05226-5

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The downregulation of circGMCL1 lowered ANXA7 expression by sponging miR-124-3p, thereby decreasing autophagy in epithelial cells and increasing NLRP3 inflammasome-mediated pyroptosis and release of proinflammatory cytokines. This resulted in aggravation of colitis and damage to the intestinal barrier function. ANXA7, annexin 7, ORF Open Reading Frame, IL interleukin.