Fig. 2. Maximum likelihood (RAxML) phylogenetic comparison of 193 Family 1 UDP-glycosyltransferases (UGTs) from N. benthamiana and A. thaliana and nine UGT sequences previously shown to be active on geraniol or iridoid substrates.

Groups A-P are annotated according to the nomenclature used by Caputi et al. 2012³³. Labeled taxa indicate enzymes in which Cas9-mediated targeted mutations were subsequently introduced. Filled gray circles at nodes indicate bootstrap supports >95. Scale bar represents the number of substitutions per site. A tree with all taxa and bootstrap values is provided in Supplementary Fig. 1.