Table 2.
Comparison between CSF and neuroimaging (MRI, OCT) data of the MSpostvacc and MSreference cohorts
| MSpostvacc | MSreference | ||
|---|---|---|---|
| Clinical data (number of patients/total) | |||
| Clinical symptom during onset due to lesion(s) in the area of Brain Brainstem Optic nerve Spinal chord Brain and Spinal chord |
3/5 (60%) 3/5 (60%) 2/5 (40%) 1/5 (20%) |
7/15 (47%) 4/15 (27%) 5/15 (33%) 1/15 (7%) |
|
| Evidence for other and/or previous autoimmune diseases | 1/5 (20%) | 2/15 (13%) | |
| Family history positive for neuroimmunological disease(s) | 1/5 (20%) | 4/15 (27%) | |
| CSF data (Mean ± SD or n/total) (n) | |||
| Time interval clinical onset to CSF analysis (days) | 27 ± 28(5) | 34 ± 9(13) | |
| Cell count(per µl) | 5.60 ± 1.52(5) | 6.29 ± 7.63(14) | |
| CSF spec. OCB | 5/5 (100%) | 13/14 (93%) | |
| Protein (mg/dl) | 32.20 ± 11.78(5) | 36.48 ± 13.33(12) | |
| Albumin quotient (CSF/Serum) | 4.39 ± 1.58(5) | 5.14 ± 2.23(11) | |
| IgG quotient (CSF/Serum) | 4.22 ± 2.48(5) | 3.69 ± 2.34(12) | |
| IgM quotient(CSF/Serum) | 4.98 ± 8.07(5) | 1.49 ± 1.78(10) | |
| IgA quotient (CSF/Serum) | 1.56 ± 0.83(5) | 2.55 ± 2.47(9) | |
| MRI data (number of patients with T2w-hyperintens lesions/total) | |||
| Number of lesions Cerebral 0 – 5 6 – 10 11 – 20 >20 / confluent Cervical spinal chord 0 1 – 5 >5 Thoracic spinal chord 0 1 – 5 >5 |
1/5 (20%) 1/5 (20%) 0/5 (0%) 2/5 (40%) 3/4 (75%) 0/4 (0%) 1/4 (25%) 1/4 (25%) 2/4 (50%) 1/4 (25%) |
3/15 (20%) 4/15 (27%) 4/15 (27%) 4/15 (27%) 7/15 (47%) 7/15 (47%) 1/15 (7%) 10/15 (67%) 4/15 (27%) 1/15 (7%) |
|
| Cerebral MRI | |||
| Periventricular | 5/5 (100%) | 14/15 (93%) | |
| (Juxta-)cortical | 4/5 (80%) | 13/15 (87%) | |
| Infratentorial | 4/5 (80%) | 9/15 (60%) | |
| Unspecific/subcortical | 4/5 (80%) | 14/15 (93%) | |
| Nervus opticus | 2/5 (40%) | 1/15 (7%) | |
| Spinal | 1/5 (20%) | 3/10 (30%) | |
| Spinal MRI | |||
| Cervical spinal cord | 1/4 (25%) | 6/15 (40%) | |
| Thoracic spinal cord | 3/5 (60%) | 5/15 (30%) | |
| OCT data all eyes | |||
| Number of patients | 5 | 15 | |
| Number of eyes | 10 | 30 | |
| TMV (mm3) | 2.04 ± 0.11 | 2.15 ± 0.09 | |
| GCIPL (μm) | 0.53 ± 0.06 | 0.58 ± 0.05 | |
| INL (μm) | 0.24 ± 0.02 | 0.25 ± 0.02 | |
| pRNFL (μm) | 91.70 ± 10.55 | 96.14 ± 9.26 | |
| OCT data eyes without a history of optic neuritis | |||
| Number of patients | 5 | 15 | |
| Number of eyes | 8 | 24 | |
| TMV (mm3) | 2.05 ± 0.12 | 2.14 ± 0.10 | |
| GCIPL (μm) | 0.55 ± 0.05 | 0.58 ± 0.04 | |
| INL (μm) | 0.23 ± 0.02 | 0.25 ± 0.02 | |
| pRNFL (μm) | 91.50 ± 11.88 | 96.63 ± 8.78 | |