Table 3.
Genotype and Allele Frequencies of rs17846866 and rs1501299 SNPs in the ADIPOQ Gene Were Compared Between T2DM and Healthy Controls
| Genotypes/Allele (rs17846866) | T2DM (n=96) | Controls (n=96) | ORs | 95% CI | p-value |
|---|---|---|---|---|---|
| TT (Genotype) | 50 (52.1%) | 69 (71.9%) | |||
| TG (Genotype) | 32 (33.4%) | 23 (23.9%) | 1.92 | 1.01–3.66 | 0.04 |
| GG (Genotype) | 14 (14.5%) | 04 (4.2%) | 4.83 | 1.50–15.55 | 0.004 |
| TG+GG vs TT (Dominant Model) | 46 (47.9%) | 27 (28.1%) | 2.35 | 1.29–4.27 | 0.004 |
| TT+GG vs TG (Co-Dominant Model) | 64 (66.6%) | 73 (76.1%) | 0.63 | 0.33–1.18 | 0.15 |
| TT+TG vs GG (Recessive Model) | 82 (85.5%) | 92 (95.8%) | 0.25 | 0.08–0.80 | 0.01 |
| T (allele) | 132 (0.68) | 161 (0.84) | |||
| G (allele) | 60 (0.32) | 31 (0.16) | 2.36 | 1.44–3.85 | 0.0005 |
| Genotypes/Allele (rs1501299) | |||||
| AA (Genotype) | 19 (19.8%) | 41 (42.7%) | |||
| AC (Genotype) | 40 (41.7%) | 24 (25%) | 3.59 | 1.71–7.56 | 0.0005 |
| CC (Genotype) | 37 (38.5%) | 31 (32.3%) | 2.57 | 1.24–5.31 | 0.009 |
| AC+CC vs AA (Dominant Model) | 77 (80.2%) | 55 (57.3%) | 3.02 | 1.58–5.75 | 0.0006 |
| AA+CC vs AC (Co-Dominant Model) | 56 (58.3%) | 72 (75%) | 0.46 | 0.25–0.86 | 0.01 |
| AA+AC vs CC (Recessive Model) | 59 (61.5%) | 65 (67.7%) | 0.76 | 0.42–1.37 | 0.36 |
| A (allele) | 78 (0.41) | 106 (0.55) | |||
| C (allele) | 114 (0.59) | 86 (0.45) | 1.83 | 1.22–2.74 | 0.003 |