Table 1.

Features of injection sites, hyaluronic acid dose, type of injection, the anatomical layer to be injected, and the needle/cannula use

Injection Site	Hyaluronic Acid Injection (Range)	Type of Injection	Anatomical Layer	Needle/Cannula
Symphysis	0.2–0.3 mL	Bolus release	Over the periosteum	Needle
Para-symphysis	0.1–0.2 mL	Bolus release	Over the periosteum	Needle
Supplementary injections lateral to the para-symphisis (before mandibular septum)	0.1 mL	Bolus release	Over the periosteum	Needle
Gonial angle	0.3–0.5 mL	Bolus release	Over the periosteum	Needle
Mandibular ramus	0.5–1 mL	Retrograde release	Subcutaneous tissue (between the SMAS and the parotid fascia)	Cannula
Mandibular body	0.5–1 mL	Retrograde release	Subcutaneous tissue (under the platysma)	Cannula
Cutaneous part of the lower lip	1–1.5 mL	Retrograde release	Subcutaneous tissue (fatty fibrotic perioral tissue)	Cannula

SMAS = superficial musculoaponeurotic system.