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. Author manuscript; available in PMC: 2023 Jan 13.
Published in final edited form as: Nature. 2022 Jul 13;607(7919):610–616. doi: 10.1038/s41586-022-04939-z

Figure 3: α-solenoid junctions, supported by β-propellers of SEH1L and SEC13, complete the GATOR2 scaffold.

Figure 3:

(a) Four α-solenoid junctions, stabilized by adjacent SEH1L and SEC13 β-propellers, complete the GATOR2 scaffold.

(b) Two views of the WDR24-WDR59 α-solenoid junction. The helical interface is supported by contacts between WDR59 and SEH1LWDR24 and between WDR24 and SEC13WDR59. For a detailed representation of the helical interface, see Extended Data Figure 9.

(c) WDR24 completes SEH1LWDR24 by β-blade donation. The incorporated SEH1L interacts with the WDR24 β-propeller, the WDR24 solenoidal domain, the WDR59 solenoidal domain, and the MIOS CTD.

(d) Detailed view of the β-blade donation from WDR24 to complete SEH1LWDR24. WDR24 contributes the three innermost strands of the seventh SEH1L propeller blade.