Table 1.

Subgroup analysis in groups vaccinated with mRNA vaccines and non-vaccinated.

	Vaccinated		Non vaccinated
Study; Subgroup	Rate	95 % CI	Rate	95 % CI	p value
Biochemical pregnancy rate
Aharon, 2021	0.756	0.637–0.842	0.73	0.678–0.774
Morris, 2021	0.80	0.641–0.90	0.739	0.638–0.819
Aizer, 2022	0.264	0.207–0.327	0.288	0.211–0.376
Avraham, 2022	0.047	0.017–0.099	0.098	0.053–0.161
Aharon, 2022	0.738	0.679–0.798	0.749	0.718–0.78
Pooled (95 % CI)	0.44	0.31–0.63	0.5	0.4–0.62	0.496
I2	97.10 %		96.40 %
Clinical pregnancy rate
Aharon, 2021	0.634	0.509–0.738	0.569	0.516–0.623
Morris, 2021	0.657	0.492–0.792	0.625	0.521–0.729
Aizer, 2022	0.25	0.194–0.313	0.264	0.167–0.313
Avraham, 2022	0.328	0.248–0.417	0.331	0.252–0.418
Aharon, 2022	0.595	0.527–0.663	0.637	0.602–0.673
Safrai, 2022	0.19	0.086–0.341	0.19	0.086–0.341
Odeh-Natour, 2022	0.440	0.224–0.522	0.50	0.260–0.740
Pooled (95 % CI)	0.42	0.32–0.56	0.43	0.33–0.55	0.574
I2	93.20 %		95.40 %
Ongoing pregnancy rate
Aharon, 2021	0.667	0.54–0.765	0.561	0.507–0.614
Morris, 2021	0.657	0.492–0.792	0.523	0.420–0.624
Aizer, 2022	0.245	0.190–0.308	0.227	0.161–0.305
Aharon, 2022	0.475	0.404–0.545	0.536	0.497–0.574
Pooled (95 % CI)	0.48	0.33–0.70	0.46	0.38--0.57	0.173
I2	95.20 %			91 %
Estradiol
Author, Year	Estradiol (pMol/l)	95 % CI	Estradiol (pMol/l)	95 % CI
Safrai, 2022	8869.8	3466.2–14273.4	6486.6	1730.8–11242.4
Avraham, 2022	5896.69	5113.34–6680.04	6199.54	5358.01–7041.07
Aharon, 2022	2559.4	1188.2–3930.6	2513.7	1257.6–3769.8
Odeh Natour, 2022	2070	921–2919	1637	1028–2682
Pooled (95 % CI)	4074.25	2191.4–7574.7	3623.6	1859.5–7061.1	0.182
I2	93.60 %		92.70 %