Table 2.

Subgroup analysis in groups before and after vaccination with Gam-COVID-Vac vaccine.

	Pre vaccination		Post vaccination
Study; Subgroup	Testosterone level	95 % CI	Testosterone level	95 % CI	p value
Testosterone
Rozhivanov, 2021	16.5	14.0–22.1	16.7	14.0–22.1
Elagin, 2021	22.20	17.65–30.63	17.25	13.00–19.85
Drapkina, 2021	9.60	8.30–12.8	11.80	9.40–13.2
Pooled (95 % CI)	15.15	9.37–24.48	14.88	11.18–19.82	0.635
I2	86.90 %		89.40 %
Spermatozoa concentration	Concentration	95 % CI	Concentration	95 % CI
Rozhivanov, 2021	70.0	51.0–112.0	71	53–102
Elagin, 2021	86.00	49.75–117.25	103.00	59.0–116.0
Drapkina, 2021	45.0	25.0–83.0	53.5	32.0–79.0
Pooled (95 % CI)	69.94	49.77–98.29	75.49	49.82–114.4	0.098
I2	42.70 %		84.10 %
Progressive Motility	Progressive Motility	95 % CI	Progressive Motility	95 % CI
Rozhivanov, 2021	0.67	0.6–0.74	0.64	0.58–0.7
Elagin, 2021	0.2478	0.178–0.316	0.2376	0.159–0.315
Drapkina, 2021	0.46	0.325–0.58	0.455	0.28–0.6
Pooled (95 % CI)	0.43	0.24–0.77	0.41	0.23–0.75	0.906
I2	96.50 %		95.6
Normal forms	Normal forms	95 % CI	Normal forms	95 % CI
Rozhivanov, 2021	0.09	0.06–0.15	0.09	0.07–0.15
Elagin, 2021	0.07	0.05–0.1175	0.08	0.05–0.15
Drapkina, 2021	0.02	0.02–0.03	0.02	0.020.03
Pooled (95 % CI)	0.05	0.02–0.13	0.05	0.02–0.15	0.21
I2	92 %		92.1
FSH levels	FSH levels	95 % CI	FSH levels	95 % CI
Elagin, 2021	5.08	2.96–7.20	4.88	2.43–7.33
Drapkina, 2021	4.80	3.10–6.40	4.80	3.20–7.00
Pooled (95 % CI)	4.91	3.98–6.13	4.84	3.67–6.38	0.75
I2	0.00 %		0.00 %
LH levels	LH levels	95 % CI	LH levels	95 % CI
Elagin, 2021	4.05	3.23–4.6	4.10	2.92–5.2
Drapkina, 2021	3.20	2.10–4.36	4.30	2.60–5.5
Pooled (95 % CI)	3.76	3.04–4.66	4.2	3.54–4.98	0.23
I2	47.50 %		0.00 %