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. Author manuscript; available in PMC: 2022 Dec 13.
Published in final edited form as: Clin Cancer Res. 2022 Jun 13;28(12):2587–2597. doi: 10.1158/1078-0432.CCR-21-3215

Figure 5. Pathways affected by germline variants or somatic mutations in bTNBC with pCR and RD.

Figure 5.

(A, B) Oncoplots of germline and somatic mutations in COSMIC genes ordered by pathologic response. (C) Significantly Germline and somatic variants pathway associations. Pathways with permutation P-values <0.05 are shown. (D) Multivariate analysis of association between pathologic response and tumor mutation burden (TMB) and the GeparSixto and tumor inflammation (TIS) gene signatures.