Table 4.

Preclinical studies evaluation of the actions of exosomal microRNA in hepatic ischemia-reperfusion injury.

miRNA	Expression	Donor cell	Recipient cell	Exosome isolation	Main function
miR-20a194	upregulation	ucMSCs	LO2, HepG2	ultracentrifugation	alleviate the abnormal expression of genes related to apoptosis and autophagy (active caspase-3, mTOR, P62, LC3II)
miR-1246195	upregulation	ucMSCs	LO2	kit	protect hepatocytes against I/R injury via modulating the differentiation of Tregs and Th17 cells
miR-1246196	upregulation	ucMSCs	LO2	ultracentrifugation	induce anti-apoptotic and pro-survival effects in LO2 cells and ameliorate I/R-induced hepatic dysfunction
miR-124-3p197	upregulation	BMSCs	hepatocytes	ultracentrifugation	reduce ferroptosis of ischemic cells by inhibiting STEAP3

ucMSCs, umbilical cord mesenchymal stem cells; I/R, ischemia-reperfusion; BMSCs, bone marrow-derived mesenchymal stem cells; STEAP3, prostate six transmembrane epithelial antigen 3; Tregs, regulatory T cells.