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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2022 Apr 6:101063. doi: 10.1016/j.preteyeres.2022.101063

FIGURE 1. Schematic diagram of the conventional outflow pathway for aqueous humor drainage.

FIGURE 1.

The arrows schematically indicate the flow patterns aqueous humor, i.e. from the anterior chamber, across the trabecular meshwork (TM) toward Schlemm’s canal. The regions of the trabecular meshwork (TM), from inner to outer are: the uveal meshwork, corneoscleral meshwork, and the juxtacanalicular or cribriform meshwork. Aqueous humor flows through the intercellular spaces of the TM and crosses the inner wall of Schlemm’s canal via two different routes: intercellular and transcellular. Resistance to aqueous humor flow increases progressively from the inner TM to the juxtacanalicular region, where intercellular spaces narrow and the cribiform TM and inner wall of Schlemm’s canal interact. Adapted from Llobet et al, Physiology, 2003, 18: 205–209 with permission (license number 1139632-1).