Skip to main content
. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2022 Apr 6:101063. doi: 10.1016/j.preteyeres.2022.101063

FIGURE 4. Transplanted trabecular meshwork stem cells (TMSCs) reduce intraocular pressure (IOP), increase outflow facility, preserve retinal ganglion cell (RGC) function, and prevent RGC loss in Tg-MyocY437H mice.

FIGURE 4.

(A) Day-time IOP was measured in wildtype mice (WT, n=26), Tg-MyocY437H mice (Tg, n=26), Tg mice treated with basal medium (Tg-Sham, n=26) and Tg mice with TMSC transplantation (Tg-TMSC, n=26). (B) Night time IOP was measured in WT mice (n=17) and Tg-MyocY437H mice (n=24) before treatment and 2 months post treatment. Data are presented as mean ± SD. (C) Outflow facility was evaluated 2 months after TMSC transplantation (n=6 eyes/group). (D) Averaged P1 amplitude in pattern electroretinogram (PERG) (n = 10 eyes/group). (E) RGC numbers counted on the retinal sections in each group (n = 12–16 sections/eyes, and 4–6 eyes/group). Data are presented as mean ± SD. Two-way ANOVA (A) or one-way ANOVA (B,C,E) followed by Tukey’s multiple comparisons test. *p<0.05, **p<0.01, ***p<0.001, **** p<0.0001. Modified from Xiong et al. eLife, 2021, 10:e63677 under the Creative Commons Attribution License.