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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2022 Apr 6:101063. doi: 10.1016/j.preteyeres.2022.101063

FIGURE 7. Mesenchymal stem cell (MSC) transplantation decreases intraocular pressure (IOP) in a rat model of ocular hypertension.

FIGURE 7.

(a) IOP was monitored over time in both eyes of rats that received episcleral vein cauterization (EVC) (right eye (RE)) or not (left eye (LE)). IOP measurements in REs are reported for the following groups: eyes injected with 5 × 105 MSCs (EVC + MSCs, green symbols; n = 12), eyes injected with culture medium alone (EVC + MEM, red symbols; n = 10), or normotensive eyes injected with 5 × 105 MSCs (MSCs, black symbols; n = 5). (b) Individual average change in IOP (ΔIOP = RE IOP − LE IOP) from injection to sacrifice times for both EVC + MSCs and EVC + MEM groups. *p <0.05, **p <0.05, ***p <0.001 vs. EVC + MEM. dMSCs differentiated mesenchymal stem cells, MEM minimum essential medium. Reproduced under the Creative Commons CC BY license from Roubeix C, Godefroy D, Mias C, et al. Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma. Stem Cell Res Ther. 2015;6(1):177. doi:10.1186/s13287-015-0168-0.