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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2022 Apr 6:101063. doi: 10.1016/j.preteyeres.2022.101063

FIGURE 8. Replacement of endogenous saponin‐depleted human trabecular meshwork (HTM) cells with cultured HTM cells.

FIGURE 8.

Transplanted replacement HTM cells (added at the time indicated) restored the intraocular pressure homeostatic response to 2x pressure elevation, which had been compromised by saponin-induced depletion of endogenous HTM cells. “1x” refers to imposition of normal perfusion pressure, while “2x” refers to a doubling of pressure. Flow has been normalized to baseline values. Data shown are mean for six experiments using separate anterior segments and error bars represent the SEM with significance by one-way ANOVA where * indicates p < .05 and ** indicates p < .001. Abu-Hassan et al. Stem Cells. 2015;33:751–761 with permission license # 1139632-3