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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Trends Cell Biol. 2022 Apr 25;32(10):841–853. doi: 10.1016/j.tcb.2022.03.012

Fig.3. Mitophagy plays key role in degrading impaired mitochondria.

Fig.3

Mitophagy selectively eliminates damaged mitochondria. Mitochondrial injury can cause mitochondrial membrane depolarization and trigger mitophagy. Mitophagy receptors; PTEN Induced Kinase 1 (PINK1), PARKIN, FUN14 Domain Containing 1 (FUNDC1), BCL2 Interacting Protein 3 (BNIP3), NIX can initiate mitophagosome formation. Induction of mitophagy is followed by lysosome mitophagosome fusion, forming the mitolysosome. Impaired mitophagy can lead to the accumulation of defective mitochondria, inflammation, and worsening kidney injury.