Table 3.
Proportion of the associations of placental abruption and preeclampsia with Autism Spectrum Disorder (ASD) that is independent of preterm birth (gestational age at birth <37 weeks)
| Hazard ratio (95% CI)1 |
% mediated through preterm birth | % independent of preterm birth | P for interaction complication x preterm birth | |||
|---|---|---|---|---|---|---|
| Total | Indirect through preterm birth | Direct or indirect not through preterm birth | ||||
|
| ||||||
| Placental abruption | 1.43 (1.18, 1.73) | 1.12 (1.09, 1.15) | 1.27 (1.04, 1.54) | 37 | 63 | 0.94 |
| Preeclampsia | 1.23 (1.14, 1.32) | 1.04 (1.03, 1.05) | 1.18 (1.10, 1.27) | 21 | 79 | 0.30 |
1
From proportional hazards models with age at first diagnosis of ASD as the outcome adjusted for maternal age, country of origin, cohabitation with the child’s father, education level, parity, height, early-pregnancy body mass index, smoking during pregnancy, presence of a diagnosis of ASD in the mother or the father, maternal polycystic ovarian syndrome, and infant sex and year of birth. The association between each complication and preterm birth was modeled with use of logistic regression.