Figure1: Generation of CIII^KO-AD mice.

(A) breeding scheme to obtain CIII^KO-AD animals. (B) Cartoon depicting the induction of Cre-recombinase and the consequent excision of exon 2 of Uqcrfs1 gene encoding for RISP. (C) Cartoon depicting the induction schedule with tamoxifen injections. (D) PCR products showing the tissue-specific excision of exon 2 of Uqcrfs1 gene after tamoxifen induction. (E) qPCR amplifying exon 2 of Uqcrfs1 gene, showing the decrease of the WT allele in the genomic DNA from CIII^KO-AD animals’ cortex. (F) qPCR amplifying recombined Uqcrfs1 gene, showing the recombination of the excised gene in the genomic DNA from CIII^KO-AD animals’ cortex.