Table 1.
Patient demographics and disease characteristics
| Characteristic | Switching (n = 118) | Continuous (n = 120) | Total (n = 238) |
|---|---|---|---|
| Mean (SD) age at informed consent, years | 46.1 (13.95) | 43.7 (13.69) | 44.9 (13.84) |
| Gender, n (%) | |||
| Male | 81 (68.6) | 76 (63.3) | 157 (66.0) |
| Female | 37 (31.4) | 44 (36.7) | 81 (34.0) |
| Ethnicity, n (%) | |||
| Hispanic or Latino | 18 (15.3) | 18 (15.0) | 36 (15.1) |
| Not Hispanic or Latino | 100 (84.7) | 102 (85.0) | 202 (84.9) |
| Race, n (%) | |||
| Asian | 2 (1.7) | 0 (0.0) | 2 (0.8) |
| Black or African American | 2 (1.7) | 0 (0.0) | 2 (0.8) |
| Native Hawaiian or other Pacific Islander | 1 (0.8) | 0 (0.0) | 1 (0.4) |
| White | 113 (95.8) | 119 (99.2) | 232 (97.5) |
| Other | 0 (0.0) | 1 (0.8) | 1 (0.4) |
| Mean (SD) weight at baseline/randomization, kg | 89.04 (20.94)/89.43 (20.89) | 90.22 (20.60)/90.26 (20.51) | 89.63 (20.72)/89.85 (20.66) |
| Mean (SD) BMI at baseline/randomization, kg/m2 | 29.54 (6.42)/29.67 (6.39) | 30.77 (6.72)/30.78 (6.70) | 30.16 (6.58)/30.23 (6.55) |
| Mean (SD) PASI score at baseline/randomization | 20.42 (7.57)/3.41 (3.09) | 20.54 (7.50)/3.73 (3.48) | 20.48 (7.52)/3.57 (3.29) |
| Mean (SD) sPGA score at baseline/randomization | 3.2 (0.42)/1.4 (0.81) | 3.3 (0.45)/1.5 (0.90) | 3.3 (0.44)/1.4 (0.85) |
| ADA at baseline, n (%) | |||
| Positive | 16 (13.6) | 8 (6.7) | 24 (10.1) |
| Negative | 99 (83.9) | 110 (91.7) | 209 (87.8) |
| Not reportable | 3 (2.5) | 2 (1.7) | 5 (2.1) |
| ADA at randomization, n (%) | |||
| Positive | 104 (88.1) | 103 (85.8) | 207 (87.0) |
| Negative | 14 (11.9) | 17 (14.2) | 31 (13.0) |
| nAb at baseline, n (%) | |||
| Negative | 115 (97.5) | 118 (98.3) | 233 (97.9) |
| Not reportable | 3 (2.5) | 2 (1.7) | 5 (2.1) |
| nAb at randomization, n (%) | |||
| Positive | 52 (44.1) | 49 (40.8) | 101 (42.4) |
| Negative | 66 (55.9) | 71 (59.2) | 137 (57.6) |
ADA antidrug antibody, BMI body mass index, nAb neutralizing antidrug antibody, PASI Psoriasis Area and Severity Index, SD standard deviation, sPGA Static Physician’s Global Assessment of psoriasis