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. 2022 Aug 19;195(3):263–274. doi: 10.1007/s10549-022-06698-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Principle component analysis using the three BluePrint signature gene sets (Basal-type, N = 28, panels a and d; Luminal-type, N = 58, panels b and e; HER2-type, N = 4, panels c and f). The x-axis shows variance explained for the first principle component (PC) and the y-axis show the variance explained for the second PC of the correspondent BluePrint signature gene set. a–c Clustering of Basal-single-type, Luminal-single-type, and HER2-single-type samples based on BluePrint signature genes. d–f Clustering of Luminal-Basal-type and Luminal-HER2-type based on BluePrint signature genes. a–c shows coloring of single subtype samples (blue, Luminal-single-type; green, HER2-single-type; red, Basal-single-type) whereas the dual subtype samples are colored grey. d–f shows this in reverse where the dual subtypes are colored (yellow, Luminal-HER2-type; pink, Luminal-Basal-type) and the single subtypes are shown in grey. The ellipses reported in each subfigure illustrate the 80% confidence intervals of the single and dual subtypes