Fig. 4.

BluePrint (BP) dual subtype classification compared with Burstein’s classification of triple-negative breast cancer tumors [12]. a The inner circle contains percentages of the BP Basal-single-type and BP Luminal-Basal-type. The outer circle illustrates the correspondent Burstein classification into Basal-like immuno-activated (BLIA), Basal-like immuno-suppressed (BLIS), Luminal androgen receptor (LAR), or Mesenchymal (MES). b) Samples with the Luminal-Basal-type were split based on standard BluePrint classification to illustrate their distribution over BLIA, BLIS, LAR, and MES subtypes. Significant differential classification of Burstein subtypes was assumed at a p-value ≤ 0.05 determined with a Chi-Square test of Independence between subtypes