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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Alzheimers Dement. 2022 Mar 12;19(1):79–96. doi: 10.1002/alz.12646

Figure 2. Aβ 37 is an analyte more sensitive to chemical modulations of γ-secretase activity.

Figure 2.

a) Indicated concentrations and ratios of Aβs secreted from iPSC-derived human neurons (means ± SD, n=6, Non-paired Student’s t-test: ***, p<0.001; ****, p<0.0001). b) Aβs secreted from HEK293-swAPP cells treated with DAPT from 10 μM down to 1.1 pM (n=2 technical replicates; means ± SEM). c) Molecular representation of the GSM4. d-e) Aβs secreted from HEK293-swAPP cells and on human iPSC-derived neurons treated with serial doses of GSM4 (n=2 technical replicates; means ± SEM).