Table 1.

Aβs secretion from PS dKO 293 cells co-transfected with WT or mutant PSEN1 and APP-C99 (pg/ml)

	AOO (yrs)	Aβ x-37	Aβ x-38	Aβ x-39	Aβ x-40	Aβ x-42	Aβ x-43
WT-PSEN1		1546.54	1478.58	947.71	19945.49	1832.06	28.05
WT-PSEN1		1424.56	1521.39	846.68	20513.23	2026.34	31.15
WT-PSEN1		1367.12	1368.03	863.40	16696.32	1745.90	20.95
D40del (delGAC)	48.00	1492.97	1636.89	1072.35	20615.23	1988.16	34.76
E69D	55.00	976.90	1123.85	704.64	13673.39	1319.32	22.52
A79V	53.00	605.65	1543.53	610.41	13205.98	1589.18	35.90
V82L	53.00	398.56	639.00	740.00	27083.21	2073.23	284.99
I83T	55.00	672.28	907.30	593.69	16218.21	2051.43	40.15
L85P	20.00	290.93	468.71	444.23	11827.96	2620.52	363.14
V89L (G>C)	46.00	625.01	1407.48	644.92	14485.76	2403.17	43.10
C92S	53.50	794.28	1226.15	877.23	26838.88	4006.24	56.56
V94M	53.00	981.35	1062.39	621.72	12736.50	1270.96	27.14
V96F	52.50	711.19	0.00	683.74	15341.04	3403.84	48.53
V97L	36.50	922.72	1036.18	813.71	17445.85	2012.16	29.87
T99A	43.00	1392.16	1650.27	985.70	25047.81	2916.71	56.56
F105I	53.00	925.33	1131.90	1073.06	20655.24	2999.07	45.89
F105V	52.00	717.59	849.09	906.59	17628.17	2347.69	41.16
L113P	43.00	648.77	434.20	971.31	6215.50	1515.77	11.93
Y115D	29.00	642.87	1292.59	1171.87	19089.38	9167.92	109.59
Y115H	35.00	438.87	405.68	558.27	6179.35	1526.73	34.76
T116N	35.00	612.20	815.37	686.76	9435.60	2464.06	22.52
T116I	48.00	528.93	1395.08	605.99	9469.68	2122.29	11.93
T116R	35.00	317.01	318.65	412.02	8548.74	5111.09	178.09
P117A	35.00	177.26	393.95	246.03	3299.15	1278.66	22.52
P117L	30.25	622.35	1100.84	740.94	14392.16	4989.74	44.97
E120D (A>T)	48.00	920.11	1462.01	1015.48	22045.57	3963.11	51.06
E120K	39.00	394.08	389.60	548.73	14054.53	6895.07	127.82
I83_M84del	36.00	406.87	759.44	590.30	26730.13	5044.51	733.95
E120G	30.00	77.07	160.10	249.06	2583.38	801.98	11.93
L134R	53.00	1204.35	2090.92	927.85	24127.90	3780.80	58.05
N135D	35.00	297.76	407.35	504.90	8317.60	1951.06	44.05
N135Y	32.00	477.90	355.12	444.23	11388.10	5490.94	231.68
N135S	33.00	209.07	232.58	264.49	5361.16	1807.99	48.53
M139T	49.00	807.04	859.80	812.83	13961.76	2062.33	27.14
M139I	37.00	1577.28	1005.53	2096.57	18302.15	3898.40	20.78
M139K	37.00	396.88	481.47	298.63	10516.99	1754.42	58.79
M139V	41.00	1266.82	723.21	1289.09	15074.84	3165.84	32.40
I143N	47.50	432.78	1275.87	279.24	4485.32	1958.70	18.92
I143M	50.00	464.09	1087.71	384.61	8034.80	1499.32	11.93
I143V	55.00	789.77	1354.78	679.03	12497.59	1911.76	29.87
I143T	35.00	591.71	1094.57	441.38	7771.47	2244.30	20.78
I143F	55.00	349.38	893.97	355.55	9068.61	1247.87	18.92
M146V	40.00	583.19	985.19	563.38	17117.29	2609.66	34.76
M146I	45.00	492.76	967.76	512.13	14485.76	2040.52	34.76
M146L	43.00	392.49	604.90	377.11	9150.66	1670.19	14.58
TI47I	42.00	508.29	1089.76	1340.52	7827.06	2536.88	0.00
T147P	32.00	1179.10	1362.78	899.59	23960.35	2068.87	41.16
L150P	60.00	584.89	3256.36	524.70	25857.23	2927.55	921.04
L153V	36.00	608.59	1164.25	656.10	18447.80	4692.06	58.79
Y154C	41.00	255.54	384.73	365.07	7412.62	975.66	430.89
Y154N	40.00	265.76	581.63	423.46	18960.09	3110.63	434.89
H163P	33.00	237.08	405.68	422.48	13600.92	4220.69	91.26
H163R	45.00	251.50	524.26	379.27	10482.86	1736.93	24.14
H163Y	47.00	327.94	705.57	463.32	12615.87	1657.06	28.53
A164V	75.00	926.58	840.14	590.30	11165.17	973.45	16.87
W165G	36.00	1277.43	1037.67	3563.53	24429.23	7449.12	52.68
W165C	42.00	3089.53	1182.58	4801.76	27899.21	5727.84	46.78
L166del	38.00	411.36	753.14	932.06	8040.98	1879.00	20.78
L166V	42.00	112.13	172.27	242.97	4767.79	885.02	38.08
L166H	30.00	397.63	5249.21	589.92	16246.34	9568.57	59.51
L166R	37.00	361.47	366.21	345.24	13135.11	3096.55	763.49
L166P	15.00	212.08	219.58	335.86	4949.36	2087.41	464.24
I167del	38.00	1279.00	2180.40	1938.94	26983.90	5831.77	44.97
S169del	42.00	985.42	1991.05	1924.98	30664.73	7890.59	63.03
S169L	31.00	813.09	704.49	546.32	11730.80	5266.73	35.90
S169P	31.00	1871.47	1792.84	2431.81	19077.62	8039.78	33.60
L171P	38.00	642.68	368.70	2139.92	12098.54	2021.98	22.52
L173F	50.00	1028.02	294.91	568.07	8773.80	1389.61	0.00
L173W	26.00	1318.53	422.16	553.12	12811.22	8435.97	34.76
L174R	48.00	414.82	297.41	371.68	15294.97	5171.21	140.98
L174M	59.00	537.24	2396.63	351.57	12942.79	1995.80	55.04
F175S	61.00	1165.51	2226.42	1157.34	21737.70	2870.09	28.53
F176L	51.00	921.78	1313.38	726.70	19432.52	2001.19	16.49
F177S	30.00	990.85	690.97	1348.35	13573.62	5504.69	29.59
E184D	42.00	717.46	1011.29	850.15	20280.72	3278.52	32.50
I202F	54.00	1040.80	1006.18	974.83	14710.44	1736.55	6.32
G206A	55.00	523.71	608.72	484.22	7659.71	988.51	0.00
G206D	33.00	494.56	715.02	762.56	10576.88	1911.97	13.84
G206V	30.00	415.64	274.91	805.78	6768.73	2207.52	0.00
G206S	32.00	503.19	583.25	956.78	9633.85	2263.48	16.49
G209R	46.00	251.15	230.13	207.53	5293.68	2729.45	179.81
G209V	41.30	456.36	362.49	368.53	12096.31	4470.52	32.50
G209A	40.00	483.64	647.15	703.74	9594.65	2605.26	16.49
G209E	43.00	167.36	189.48	235.89	2397.42	575.80	0.00
S212Y	46.50	618.80	917.03	608.23	15112.27	2165.02	31.08
I213F	33.00	342.80	364.18	484.64	24415.83	6829.26	241.09
I213T	45.00	855.43	623.90	515.66	14708.16	1533.98	16.49
H214N	46.00	449.95	893.03	506.84	12122.80	1868.39	24.71
H214Y	41.00	360.04	622.25	425.59	11447.28	1480.97	16.49
H214D	55.00	733.53	520.54	468.51	11869.31	1260.43	22.89
G217D	36.00	776.16	1110.67	827.80	24482.49	3745.34	69.84
Q222H	35.00	500.79	721.01	762.56	25424.62	4361.24	117.52
L226F	33.00	136.43	174.33	164.86	5117.69	1294.78	28.05
S230R	58.00	385.87	332.75	292.65	6804.69	796.47	31.08
A231P	53.00	466.69	500.92	571.04	22119.75	3315.71	115.61
A231T	52.00	397.03	472.37	264.48	8509.63	968.69	0.00
M233T	38.00	1123.48	2991.78	1028.37	8485.56	3937.30	6.32
M233I	28.00	635.86	1110.79	884.00	14164.60	6142.56	0.00
M233V	31.00	263.95	478.70	336.58	4338.23	1683.59	0.00
M223L	46.00	219.33	350.14	114.42	5375.00	837.20	0.00
L235P	33.00	187.19	246.83	235.14	8136.71	1879.80	36.49
L235R	45.00	214.79	233.25	202.49	6802.44	1949.32	80.86
L235V	47.00	683.34	594.37	590.23	11412.50	1464.33	26.42
F237I	46.00	514.98	384.37	281.78	8452.47	874.79	0.00
F237L	47.00	752.22	533.15	431.61	11610.62	1311.43	18.83
Q223R	33.00	401.42	553.44	619.65	27309.18	5861.76	1393.90
L248P	42.00	792.17	1158.82	877.00	20660.37	4487.02	35.20
L248R	54.00	488.43	376.11	311.66	8624.73	906.10	6.32
A246P	47.00	542.04	894.98	708.99	17439.46	6312.23	88.96
Y256S	25.00	692.23	1315.93	352.04	10432.68	3902.22	799.69
P267A	45.00	918.07	1402.97	867.08	31142.12	4543.71	91.33
P267L	59.00	438.28	384.17	237.39	9861.54	1021.88	16.49
P267S	35.00	220.75	270.81	225.98	8621.72	1860.09	69.84
R278I	50.00	164.81	164.07	193.86	2787.89	351.31	212.18
R278S	39.00	144.06	299.88	159.79	6151.93	1206.30	182.45
R278T	37.00	171.79	328.12	205.02	7183.98	1465.37	256.96
R278K	40.00	169.53	437.78	162.85	9649.68	1741.75	239.27
E280A	48.00	418.70	904.10	485.47	14424.95	2706.68	76.20
E280K	48.00	687.49	1402.97	604.03	20808.60	2943.58	99.25
L282R	43.00	209.49	303.56	240.36	11095.80	1089.63	133.66
L282V	44.30	619.28	739.30	708.69	30128.05	4166.33	62.94
L282F	49.00	474.06	539.66	517.65	26497.82	2517.26	118.47
V272A	31.00	402.85	315.84	301.35	16799.08	3407.66	80.21
V272D	43.00	249.44	207.12	196.48	5926.89	782.89	117.52
F386S	48.00	289.09	491.61	355.28	14768.92	3907.38	612.41
F388L	43.00	609.74	466.37	361.16	10166.28	1088.59	13.84
F386I	50.00	268.88	447.98	221.29	8340.43	1581.78	69.10
G384A	34.00	384.43	434.87	221.29	5354.11	1784.31	124.01
L424F	57.00	930.85	1089.01	646.99	19611.88	2465.48	40.14
L424H	40.00	386.82	489.22	477.47	19637.83	4384.95	121.72
L424R	33.00	240.06	363.55	232.88	13283.99	3529.54	154.05
L424V	30.00	434.27	587.81	515.66	26126.44	4094.13	195.17
E318G	61.00	988.89	1063.06	555.84	12872.48	1213.58	16.49
E9 Del	45.00	210.15	345.40	192.10	6476.67	1207.34	173.08