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. 2022 Aug 29;13:966416. doi: 10.3389/fimmu.2022.966416

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Copyright © 2022 Valim, Martins-Filho, Gouvea, Camacho, Villela, de Lima, Azevedo, Neto, Domingues, de Medeiros Junior, Moulaz, Dias, Miyamoto, Teixeira-Carvalho, Mill and Half Dose ChAdOx Study Group

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall profile of plasma soluble mediators upon COVID-19 vaccination of seropositive subjects at baseline. The levels of chemokines (CCL11, CXCL8, CCL3, CCL4, CCL2, CCL5, CXCL10), pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-12, IFN-γ, IL-15, IL-17), regulatory cytokines (IL-1Ra, IL-4, IL-5, IL-9, IL-10, IL-13), and growth factors (FGF-basic, VEGF, PDGF, G-CSF, GM-CSF, IL-7 and IL-2) were measured in plasma samples from subjects with seropositive status at baseline in consecutive timepoints: prior (D0), after first (D28) and second (D28*) doses, including subjects receiving a half dose (ChAd Half Dose), n = 26), represented by light blue symbols on the right side of each graph compared to the reference volunteers receiving the standard dose (ChAd Full Dose), n = 7), represented by dark blue symbols on the left side of each graph. Quantification of plasma soluble mediators were carried by high-throughput Luminex Microbeads Platform as described in the Methods. The results are presented as color filled bar charts of median values expressed in fold changes in plasma concentrations (pg/mL) according to the individual baseline values (D28/D0 and D28*/D0), referred as ChAd Full (D28), ChAd Full (D28*), ChAd Half (D28) and ChAd Half (D28*). Significant differences were considered at p ≤ 0.05 and are indicated by connecting lines and # symbol for intragroup (D28 vs. D28*) and intergroup ChAd Full Dose versus ChAd Half Dose comparisons, respectively.