TABLE 3.
Beta coefficients and their bootstrap standard errors of the final overall and cancer-specific survival models calculated within the imputed training cohort.
| Variables | Overall survival |
Cancer-specific survival |
||||
| β coefficients | Bootstrap SE | p-value | β coefficients | Bootstrap SE | p-value | |
| Age, y | ||||||
| 18–39 | Reference | Reference | ||||
| 40–59 | 0.19593 | 0.27779 | 0.48060 | 0.06896 | 0.28024 | 0.80564 |
| 60–79 | 0.67730 | 0.26537 | 0.01070 | 0.35783 | 0.27253 | 0.18918 |
| 80–100 | 1.46783 | 0.27607 | <0.00001 | 1.09818 | 0.28078 | 0.00009 |
| Tumor size, cm | ||||||
| <2 | Reference | Reference | ||||
| 2–4 | 0.21352 | 0.14344 | 0.13660 | 0.24540 | 0.17694 | 0.16548 |
| ≥4 | 0.44749 | 0.13988 | 0.00138 | 0.57388 | 0.18809 | 0.00228 |
| Radiotherapy | ||||||
| None | Reference | Reference | ||||
| Beam | −0.43073 | 0.09575 | 0.00001 | −0.48371 | 0.12296 | 0.00008 |
| Beam + implants | −0.86705 | 0.11851 | <0.00001 | −1.04213 | 0.15922 | <0.00001 |
| Radiation, NOS | −0.29244 | 0.20267 | 0.14904 | −0.23287 | 0.23471 | 0.32112 |
| Implants | −0.95970 | 0.18768 | <0.00001 | −1.13098 | 0.23740 | <0.00001 |
| Chemotherapy | ||||||
| None/unknown | Reference | Reference | ||||
| Yes | −0.27861 | 0.08434 | 0.00096 | −0.19033 | 0.10500 | 0.06989 |
| Surgery | ||||||
| None | Reference | Reference | ||||
| Local tumor excision | −0.54175 | 0.11260 | <0.00001 | −0.61139 | 0.15755 | 0.0001 |
| Vaginectomy | −0.73283 | 0.14495 | <0.00001 | −0.67324 | 0.17219 | 0.00009 |
| Debulking | −0.26163 | 0.36299 | 0.47105 | −0.07539 | 0.37202 | 0.83941 |
| Number of lymph nodes removed | ||||||
| None | Reference | Reference | ||||
| 1–3 | 0.17467 | 0.30427 | 0.56593 | 0.17230 | 0.38622 | 0.65551 |
| ≥4 | −0.47991 | 0.19393 | 0.01334 | −0.36552 | 0.21715 | 0.09233 |
| Number unknown | 0.38244 | 0.40080 | 0.33999 | 0.67311 | 3.21673 | 0.83425 |
| T stage | ||||||
| T1 | Reference | Reference | ||||
| T2 | 0.23081 | 0.09139 | 0.01155 | 0.36817 | 0.12840 | 0.00414 |
| T3 | 0.41905 | 0.12574 | 0.00086 | 0.61803 | 0.14603 | 0.00002 |
| T4 | 0.82441 | 0.14587 | <0.00001 | 0.99892 | 0.16405 | <0.00001 |
| TX | 0.12220 | 0.17625 | 0.48809 | 0.27493 | 0.19949 | 0.16815 |
| N stage | ||||||
| N0 | Reference | Reference | ||||
| N1 | 0.26231 | 0.10441 | 0.01200 | 0.23417 | 0.12536 | 0.06176 |
| NX | 0.25829 | 0.14786 | 0.08066 | 0.06867 | 0.19146 | 0.71986 |
| M stage | ||||||
| M0 | Reference | Reference | ||||
| M1 | 0.66769 | 0.10629 | <0.00001 | 0.71244 | 0.13504 | <0.00001 |
| MX | −0.20732 | 0.24499 | 0.39743 | 0.10063 | 0.26910 | 0.70845 |
| Presence of other malignancies | ||||||
| No | – | Reference | ||||
| Yes | – | – | – | −0.49258 | 0.14590 | 0.00074 |
| Baseline survival | ||||||
| 3 years | 0.82548 | – | – | 0.84248 | – | – |
| 5 years | 0.74510 | – | – | 0.78676 | – | – |
SE, standard error; NOS, not otherwise specified; see Supplementary Document for details about the calculation of patient-level survival probability.