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. 2022 Aug 29;13:952587. doi: 10.3389/fphar.2022.952587

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Copyright © 2022 Chen, Ma, Pi, Wu, Zuo, Li and Ouyang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of luteolin on tumours in vivo. (A) Tumours in mice. (B) Tumour volume was measured every 2 days. Tumour volume = 0.5× maximum diameter × minimum diameter squared. (C) Tumour weight. (D) SOD content in tumours. (E) H₂O₂ content in tumours. (F) GSH content in tumours. (G) The content of IL-1 in the serum of mice was determined by ELISA. (H) Image of angiogenesis in tumours. Red indicates blood flow. (I) TUNEL staining of tumour tissues (J) Tumour tissues of control, luteolin-, and VX765-treated mice were collected, and the expression levels of NLRP3, ASC, Pro-Caspase1, Caspase1, GSDMD, Cleaved-GSDMD (N-T), and IL-1β were analysed by WB. GAPGH and β-actin were used as internal controls. (K) Immunofluorescence colocalization of the NLRP3/GSDMD proteins in mouse tumour tissues.