REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Armenian Hamster anti-cd61, PE	Invitrogen	Cat#12-0611-82
Armenian Hamster IgG, PE	Invitrogen	Cat#12-4888-81
Bacterial and virus strains
AAV8-CAG-mOstn-WPRE	Vector Biolabs	NA
AAV8-CAG-eGFP	Vector Biolabs	NA
Chemicals, peptides, and recombinant proteins
Dexamethasone	Sigma	Cat#D2915
Annexin V, Alexa Fluor 488 conjugate	Invitrogen	Cat#A13201
Annexin Binding Buffer, 5x	Invitrogen	Cat#V13246
C-type natriuretic peptide (CNP)	Sigma	Cat#N8768
Osteocrin (Ostn) (83-132) peptide	Phoenix Pharmaceuticals	Cat#028-66
Prednisolone pellets	Innovative Research of America	Cat#SG-151
Placebo pellets	Innovative Research of America	Cat#SC-111
Buprenorphine HCl	Par Pharmaceutical	NDC 42023-179-05
Silver nitrate	Sigma	Cat#10220
Gelatin type A	Sigma	Cat#G2500
Formic acid	Millipore Sigma	Cat#FX0440
Sodium thiosulfate	Sigma	Cat#72049
Napthol AS-MX Phosphate	Sigma	Cat#N4875
Fast Red TR salt	Sigma	Cat#F6760
Fluoromount-G	SouthernBiotech	Cat#0100-01
TRIzol Reagent	Invitrogen	Cat#15596026
DAPI	Invitrogen	Cat#D1306
Proteinase K	Thermo Fisher	Cat#EO0492
Pepsin	Sigma	Cat#R2283
Critical commercial assays
P1NP EIA	IDS	Cat#AC-33F1
CTX-1 EIA	IDS	Cat#AC-06F1
In Situ Cell Death Detection kit, fluorescein (TUNEL)	Roche	Cat#11684795910
CytoPainter F-actin staining kit - Green	Abcam	Cat#ab112125
PureLink RNA Mini Kit	Invitrogen	Cat#12183025
PerfeCT SYBR Green FastMix	Quantabio	Cat#95073
PrimeScript RT Reagent Kit with gDNA Eraser	Takara	Cat#RR047B
Experimental models: Cell lines
Ocy454	PMID: 25271055	NA
Experimental models: Organisms/strains
C57BL/6J Mice	The Jackson Laboratory	000,664
FVB Mice	The Jackson Laboratory	001,800
Oligonucleotides
RNAscope probe: Ostn	ACD	Cat#440791
Full list of qRT-PCR primers, see Table S1	This paper	NA
Software and algorithms
Prism v8.4	GraphPad	https://www.graphpad.com/scientific-software/prism/
ImageJ	PMID: 22,930,834	https://imagej.nih.gov/ij/
FlowJo v10.7	BD	https://www.flowjo.com/
Other
Trochar	Innovative Research of America	Cat#MP-182
Vetbond tissue adhesive	3M	Cat#1469SB
Serum separator tubes	BD	Cat#365967