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. 2022 Aug 29;13:833380. doi: 10.3389/fphar.2022.833380

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Copyright © 2022 Goldblatt, Valverde Ha, Wali, Kulkarni, Longmire, Jaramillo, Chittuluru, Fouts, Martinez-Moczygemba, Lei, Huston, Tuvim, Dickey and Evans.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exposure to Pam2-ODN attenuates allergic inflammation to OVA. (A) OVA experimental paradigm with sensitization of 20 µg OVA by intraperitoneal injection and aerosol challenges of 2.5% OVA. (B–F) Quantification of leukocytes in lung lavage for (B) total leukocytes (C) eosinophils, (D) lymphocytes, (E) macrophages, and (F) neutrophils (N = 4-5 mice). (G–J) Quantification of serum immunoglobulin concentrations by ELISA for (G) IgE, (H) OVA-specific IgE, (I) IgG, (J) IgG1, and (K) IgG2a (N = 8-9 mice). (L) Quantification of intracellular mucin content by image analysis of airway stained with PAFS (N = 4-5 mice). Bars show mean +/- SEM. p* < 0.05 by unpaired students’ t test for OVA vs. OP-OVA. P = PBS. OVA = Ovalbumin.