Fig. 3.

Male mice that lack mature B cells and immunoglobulins have increased trabecular bone. (A) IgG levels in serum. (B) Total body aBMD and LS L₃–L₆ aBMD were determined with DXA at 5‐week‐old, 12‐week‐old, and 16‐weeks of age in male muMT mice and WT littermates. *Indicates significant difference determined with Student's t test. (C) Trabecular BV/TV, Tb.N, Tb.Sp, and Tb.Th. (D) Ct.Th analyzed with high‐resolution μCT at 16 weeks of age. (E) Serum levels of P1NP (bone formation marker) and CTX (bone resorption marker). Student's t test was used to assess the differences between WT and muMT mice. n = 8–11. *p < 0.05, **p < 0.01, ***p < 0.001. aBMD = areal BMD; BV/TV = bone volume per total volume; Ct.Th = cortical thickness; LS = lumbar spine; Tb.N = trabecular number; Tb.Sp = trabecular separation; Tb.Th = trabecular thickness; WT = wild‐type.