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. 2022 Aug 29;13:967478. doi: 10.3389/fphys.2022.967478

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Copyright © 2022 Craighead, Freeberg, McCarty, Rossman, Moreau, You, Chonchol and Seals.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expected Results. Expected results for (A) casual systolic blood pressure (SBP; primary outcome) and 24-h SBP (secondary outcome); and for (B) endothelial function measured by brachial artery flow-mediated dilation (FMD_BA; secondary outcome) in the high-resistance inspiratory muscle strength training (IMST) and moderate-intensity aerobic exercise groups across the intervention. Dashed line represents expected FMD_BA with supratherapeutic infusion of the potent antioxidant, vitamin C, in both subject groups.