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. 2022 Aug 29;10:987317. doi: 10.3389/fcell.2022.987317

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Copyright © 2022 Nichenko, Specht, Craige and Drake.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential mechanisms for induction of mitophagy in response to energetic stress. We have shown that mitoAMPK localizes to OMM and exerts control over exercise-induced mitophagy. Whether mitoAMPK coordinates with cytosolic pools of AMPK (cytoAMPK) to activate Ulk1 and initiate formation of autophagosomes is unknown. Additionally, it is unclear what roles other mitophagy-related proteins localized to mitochondria (e.g., Fundc1 and Mff) play in mitoAMPK regulation of mitochondrial quality control or the role of mitochondrial-generated ROS, potentially through Nox4.