Table 1.
Comparison of key features between K . pneumoniae Class I and Class III
|
Total (n=151) |
Class I (n=109) |
Class III (n=42) |
OR (95 % CI) |
p-value |
||
|---|---|---|---|---|---|---|
|
Sequence type | ||||||
|
ST23 |
27 (17.9 %) |
26 (23.9 %) |
1 (2.4 %) |
12.843 (1.683–97.990) |
0.002 |
** |
|
ST65 |
19 (12.6 %) |
18 (16.5 %) |
1 (2.4 %) |
8.110 (1.047–62.817) |
0.019 |
* |
|
ST86 |
14 (9.3 %) |
14 (12.8 %) |
0 (0.0 %) |
n/a |
0.011 |
* |
|
ST268 |
6 (4.0 %) |
6 (5.5 %) |
0 (0.0 %) |
n/a |
0.187 |
|
|
ST37 |
6 (4.0 %) |
0 (0.0 %) |
6 (14.3 %) |
n/a |
3.52×10−4 |
*** |
|
K loci | ||||||
|
KL1 |
29 (19.2 %) |
28 (25.7 %) |
1 (2.4 %) |
14.173 (1.862–107.883) |
0.001122 |
*** |
|
KL2 |
39 (25.8 %) |
35 (32.1 %) |
4 (9.5 %) |
4.493 (1.487–13.579) |
0.004 |
** |
|
KL20 |
9 (6.0 %) |
9 (8.3 %) |
0 (0.0 %) |
n/a |
0.063 |
|
|
KL57 |
10 (6.6 %) |
10 (9.2 %) |
0 (0.0 %) |
n/a |
0.062 |
|
|
Regulator of mucoid phenotype | ||||||
|
intact rmpA (+) |
95 (62.9 %) |
92 (84.4 %) |
3 (7.1 %) |
70.353 (19.497–253.856) |
1.285×10−18 |
*** |
|
intact rmpA2 (+) |
15 (9.9 %) |
14 (12.8 %) |
1 (2.4 %) |
6.042 (0.769–47.480) |
0.069 |
|
|
intact rmpA and/or rmpA2 (+) |
97 (64.2 %) |
93 (85.3 %) |
4 (9.5 %) |
55.219 (17.331–175.936) |
3.104×10−18 |
*** |
|
Virulence determinants | ||||||
|
Yersiniabactin (ybt) |
77 (51.0 %) |
67 (61.5 %) |
10 (23.8 %) |
5.105 (2.275–11.453) |
0.000034 |
*** |
|
Colibactin (clb) |
39 (25.8 %) |
37 (33.9 %) |
2 (4.8 %) |
10.278 (2.353–44.899) |
0.000241 |
*** |
|
Aerobactin (iuc) |
95 (62.9 %) |
91 (83.5 %) |
4 (9.5 %) |
48.028 (15.243–151.324) |
3.425×10−17 |
*** |
|
Salmochelin (iro) |
101 (66.9 %) |
97 (89.0 %) |
4 (9.5 %) |
76.792 (23.312–252.959) |
1.437×10−20 |
*** |
|
Virulence score 0 |
37 (24.5 %) |
7 (6.4 %) |
30 (71.4 %) |
0.027 (0.010–0.076) |
8.645×10−17 |
*** |
|
Virulence score 1 |
19 (12.6 %) |
11 (10.1 %) |
8 (19.0 %) |
0.477 (0.177–1.285) |
0.137 |
|
|
Virulence score 2 |
0 (0.0 %) |
0 (0.0 %) |
0 (0.0 %) |
n/a |
n/a |
|
|
Virulence score 3 |
37 (24.5 %) |
35 (32.1 %) |
2 (4.8 %) |
9.459 (2.162–41.387) |
4.63×10−4 |
*** |
|
Virulence score 4 |
19 (12.6 %) |
19 (17.4 %) |
0 (0.0 %) |
n/a |
0.002 |
** |
|
Virulence score 5 |
39 (25.8 %) |
37 (33.9 %) |
2 (4.8 %) |
10.278 (2.353–44.899) |
2.41×10−4 |
*** |
|
Antimicrobial resistance | ||||||
|
ESBL |
18 (11.9 %) |
4 (3.7 %) |
14 (33.3 %) |
0.076 (0.023–0.250) |
4.639×10−7 |
*** |
|
Carbapenemase |
12 (7.9 %) |
3 (2.8 %) |
9 (21.4 %) |
0.104 (0.027–0.406) |
1.43×10−4 |
*** |
|
EBSL and Carbapenemase |
11 (7.3 %) |
3 (2.8 %) |
8 (19.0 %) |
0.120 (0.030–0.479) |
5.55×10−4 |
** |
|
Temperature and string test | ||||||
|
Mean string length at 37 °C (cm) |
5.67 ± 0.63 |
4.04 ± 1.20 |
1.29×10−4 |
*** |
||
|
Mean string length at room temperature (cm) |
0.10 ± 0.27 |
17.32 ± 3.91 |
<0.0001 |
*** |
||
Virulence score: 0, no acquired virulence loci detected; 1, only yersiniabactin (ybt); 2, only colibactin (clb) or colibactin and yersiniabactin; 3, only aerobactin (iuc) and/or salmochelin (iro) (without yersiniabactin or colibactin); 4, aerobactin and/or salmochelin with yersiniabactin (without colibactin); and 5, yersiniabactin, colibactin, aerobactin, and/or salmochelin.
Resistance score: 0, no ESBL and no carbapenemase, irrespective of colistin resistance; 1, only ESBL, but no carbapenemase, irrespective of colistin resistance; 2, carbapenemase without colistin resistance; and 3, carbapenemase with colistin resistance.*p < 0.05, **p < 0.01, ***p < 0.001.