TABLE 1.
Clinical characteristics of patients with glioma from TCGA.
| Characteristic | Low CENP-A expression | High CENP-A expression | p-value |
|---|---|---|---|
| Number of cases | 348 | 348 | |
| WHO grade, n (%) | <0.001 | ||
| G2 | 188 (29.6%) | 36 (5.7%) | |
| G3 | 115 (18.1%) | 128 (20.2%) | |
| G4 | 6 (0.9%) | 162 (25.5%) | |
| IDH status, n (%) | <0.001 | ||
| WT | 36 (5.2%) | 210 (30.6%) | |
| Mut | 309 (45%) | 131 (19.1%) | |
| 1p/19q co-deletion, n (%) | <0.001 | ||
| Co-deletion | 137 (19.9%) | 34 (4.9%) | |
| No co-deletion | 210 (30.5%) | 308 (44.7%) | |
| Primary therapy outcome, n (%) | <0.001 | ||
| PD | 52 (11.3%) | 60 (13%) | |
| SD | 92 (19.9%) | 55 (11.9%) | |
| PR | 51 (11%) | 13 (2.8%) | |
| CR | 102 (22.1%) | 37 (8%) | |
| Gender, n (%) | 0.592 | ||
| Female | 153 (22%) | 145 (20.8%) | |
| Male | 195 (28%) | 203 (29.2%) | |
| Age, n (%) | <0.001 | ||
| ≤60 | 313 (45%) | 240 (34.5%) | |
| >60 | 35 (5%) | 108 (15.5%) | |
| Histological type, n (%) | <0.001 | ||
| Astrocytoma | 112 (16.1%) | 83 (11.9%) | |
| Glioblastoma | 6 (0.9%) | 162 (23.3%) | |
| Oligoastrocytoma | 90 (12.9%) | 44 (6.3%) | |
| Oligodendroglioma | 140 (20.1%) | 59 (8.5%) | |
| Age, median (IQR) | 39 (32, 51) | 53 (39, 63) | <0.001 |
WHO, world health organization; IDH, isocitrate dehydrogenase; WT, wild-type; MUT, mutated; PD, progressive disease; SD, stable disease; PR, partial response; CR, complete response.