TABLE 3.
The correlation of CENP-A and clinicopathologic characteristics with overall survival in patients with glioma in TCGA, and the multivariate survival model based on univariate selection (Cox regression).
| Characteristics | Total (n) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | ||
| WHO grade | 634 | ||||
| G2 and G3 | 466 | Reference | |||
| G4 | 168 | 9.496 (7.212–12.503) | <0.001 | 4.106 (1.429–11.794) | 0.009 |
| IDH status | 685 | ||||
| Mut | 439 | Reference | |||
| WT | 246 | 8.551 (6.558–11.150) | <0.001 | 2.708 (1.712–4.282) | <0.001 |
| 1p/19q co-deletion | 688 | ||||
| No co-deletion | 518 | Reference | |||
| Co-deletion | 170 | 0.226 (0.147–0.347) | <0.001 | 0.736 (0.422–1.285) | 0.281 |
| Primary therapy outcome | 461 | ||||
| PD&SD | 259 | Reference | |||
| PR&CR | 202 | 0.209 (0.120–0.366) | <0.001 | 0.302 (0.164–0.559) | <0.001 |
| Age | 695 | ||||
| ≤60 | 552 | Reference | |||
| >60 | 143 | 4.668 (3.598–6.056) | <0.001 | 4.116 (2.548–6.647) | <0.001 |
| CENP-A | 695 | ||||
| Low | 348 | Reference | |||
| High | 347 | 5.422 (4.044–7.271) | <0.001 | 1.967 (1.280–3.025) | 0.002 |
WHO, world health organization; IDH, isocitrate dehydrogenase; WT, wild-type; MUT, mutated; PD, progressive disease; SD, stable disease; PR, partial response; CR, complete response.