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. 2022 Aug 29;9:916128. doi: 10.3389/fmolb.2022.916128

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Copyright © 2022 Magnusson, Rundquist, Kim, Hellberg, Na, Benson, Gomez-Cabrero, Kockum, Tegnér, Piehl, Jagodic, Mellergård, Altafini, Ernerudh, Jenmalm, Nestor, Kim and Gustafsson.

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Proteins models led to the discovery of new potential biomarkers of complex diseases that were validated in multiple sclerosis (MS). (A) Differential predicted protein (PP) analysis of five diseases using the T_H1 (light blue) and T_reg (dark blue) models showed higher fraction of nominally significant genes than that of normal differential gene expression tests. (B) Measurement of actual protein levels of the predicted proteins in a cohort of patients with early MS [clinically isolated syndrome (CIS)] vs. healthy controls (HC) (left side of the figure) and from a cohort of MS patients pre vs. post 1-year treatment with Natalizumab (right side of the figure). sCD27 was measured in cerebrospinal fluid (CSF) using ELISA. (C) Receiver operating curve using sCD27 concentration as a single prognostic marker of NEDA at four (solid line) and 2 years (dashed line) after CIS.