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. 2022 Aug 29;15:974007. doi: 10.3389/fnmol.2022.974007

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Copyright © 2022 Li, Liu, Chen, Dai, Zhao, Liu, Song, Xiong and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of shared neurons induced pain. (A) The mechanical pain thresholds and thermal pain thresholds of the ipsilateral hind paw plantar were decreased after CNO treatment in normal mice. n = 11, paired t-test. For mechanical pain thresholds, ****P < 0.0001. For thermal pain thresholds, ****P < 0.0001. (B) The mechanical pain thresholds and thermal pain thresholds of the ipsilateral hind paw plantar did not change significantly after CNO treatment in the CFA model. n = 11, paired t-test. For mechanical pain thresholds, P = 0.7334. For thermal pain thresholds, P = 0.9560.