TABLE 3.

Probability (%) of target Css, avg > 2 mg/L or Css, avg > 4 mg/L for different colistin sulfate regimens.

Dosing regimens	Probability (%) of Css, avg > 2 mg/L				Probability (%) of Css, avg > 4 mg/L
	10 ml/min	50 ml/min	80 ml/min	120 ml/min	10 ml/min	50 ml/min	80 ml/min	120 ml/min
0.5MU q12h	74	29	21	15	4	0	0	0
1.0MU + 0.5MU q12h	85.5	37.5	28	17	7.5	0.5	0	0
1.5MU + 0.5MU q12h	94	53	42	33	28.5	3	1.5	1.5
0.5MU q8h	96.5	75	62.5	49	46	7	2.5	1
0.75MU q12h	96.5	73.5	58	45	41	7	2.5	0.5
1.0MU + 0.5MU q8h	98	77	69.5	56.5	56	16.5	12.5	7.5
1.0MU + 0.75MU q12h	98	70	59	43.5	44.5	12	6	3
1.5MU + 0.5MU q8h	98.5	82	68.5	57	66.5	20	12	7.5
1.5MU + 0.75MU q12h	97.5	81	65.5	52.5	59.5	14.5	7.5	4.5
1.0 MU q12h	99.5	88.5	78	69	76	33	23	13
1.5MU + 1.0 MU q12h	100	87	79.5	71.5	79	39	26.5	16.5
1.0MU + 0.75MU q8h	100	93	87	80.5	87	55.5	36.5	28.5

10, 000 U = 0.44mg; q12h: Every 12 h; q8h: every 8 h; C_{ss, avg}: Average steady-state plasma concentration.