Regression equation coefficients and model fitting of the quadratic model for each studied response.

Responsesa (Yi)	Coefficients						p-values		R 2
	β 1	β 2	β 3	β 12	β 13	β 23	Model	Lack of fit
TPC	23.99b	15.14	6.82	15.51	150.81b	37.23b	0.000064	0.402 113	0.95
TAC	118.95b	147.06b	50.6b	146.51	694.36b	208.11b	0.000200	0.516 828	0.93
DPPH	0.67	8.21b	1.05	32.48b	135.35b	15.88	0.000010	0.093201	0.97
ABTS	54.97b	35.11b	18.03	153.19b	378.33b	80.86	0.000072	0.567 471	0.95
FRAP	11.41b	28.53b	15.33b	40.53	202.45b	3.16	0.000209	0.286 987	0.93
CUPRAC	10.25	41.20b	26.83b	2.69	240.38b	39.54	0.001257	0.558 710	0.89

^a Y _i = β₁ Water+ β₂ Methanol+ β₃ Acetone+ β₁₂ Water × Methanol+ β₁₃ Water × Acetone+ β₂₃ Methanol × Acetone.

^bSignificant at p < 0.05.