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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2022 Feb 14;13(5):e1717. doi: 10.1002/wrna.1717

Figure 4: Alphafold modeled human TSEN tetramer.

Figure 4:

A) The archaeal tRNA splicing complex (PDB:1A79) that was used as the docking interface of the model, with two domains highlighted as nuclease domains (pink and orange), with the active sites shown as spheres and boxed, and the structural domains (green and blue). B) Alphafold models of the TSEN proteins docked onto the previous archaeal tRNA splicing complex. Boxed and labelled is a 2N′ region of the TSEN2 prediction that appears to supplement for part of TSEN15. C) The Alphafold model from part B, with the disordered regions and 2N′ truncated.