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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2022 Feb 14;13(5):e1717. doi: 10.1002/wrna.1717

Figure 5. Substrate Recognition by tRNA splicing complexes.

Figure 5.

A) The archaeal tRNA splicing complex (PDB:2GJW) bound to a BHB RNA. B) A depiction of the bulge-helix bulge (BHB-type) and bulge-helix-loop (BHL-type) tRNA intron substrate for splicing with the intron (red filled circles) and exon (blue filled circles) shown as well as the anticodon (unfilled circles) and the proximal base pair (boxed). C) The Alphafold model with a tRNA (PDB:4tra) docked onto the complex similar to the BHB with the tRNA arms oriented in the region of TSEN54.