FIGURE 2.

ST6Gal1-mediated Signaling Cascades in Cancer. The membrane bound N-glycoproteins synthesized and processed in secretory pathways (including Fas, TNFR1, β1-integrin, PECAM, VEGFR2 and EGFR among others) are α2,6 sialylated by ST6Gal1. This can affect protein cell surface retention, stability, clustering and/or activation. Through direct and indirect signaling pathways, ST6Gal1 promotes oncogenic characteristics in many cancers. The pink diamond represents α2,6 linked sialic acid, although the full glycan structure is not shown for simplification. The figure was created using Biorender (https://biorender.com).