Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PCSK9 impacts LDLC metabolism by regulating LDLR levels. (A) PCSK9 binds LDLR on hepatocyte surfaces, triggering their internalization and degradation by the lysosome. (B) In the presence of a PCSK9 inhibitor (e.g., monoclonal antibody), the prevalence of LDLR increases, leading to improved LDLC metabolism. Adapted with permission from ref (4). Copyright 2022 Mayo Foundation for Medical Education and Research.
