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. 2022 Aug 12;13(9):1510–1516. doi: 10.1021/acsmedchemlett.2c00309

Figure 3.

Figure 3

Compound 35 displaces the Beclin 1 BH3 domain from Bcl-2, but not the Bax BH3 domain. (A–F) Superpositions of 1H–15N TROSY-HSQC spectra of (A) Bcl-2 alone (black contours) or in the presence of compound 35 (red contours); (B) Bcl-2 alone (black contours) or in the presence of the Beclin 1 BH3 peptide (light blue contours); (C) Bcl-2 in the presence of compound 35 and the absence (red contours) or presence (blue contours) of the Beclin 1 BH3 peptide; (D) Bcl-2 alone (black contours) or in the presence of the Bax BH3 peptide (orange contours); (E) Bcl-2 in the presence of the Beclin 1 BH3 peptide (light blue contours) or the Bax BH3 peptide (orange contours); (F) Bcl-2 in the presence of the Bax BH3 peptide and the absence (orange contours) or presence (gray contours) of compound 35.